Title:
抗インテグリン活性を有するフルオロ-アルキル-シクロペプチド誘導体
Document Type and Number:
Japanese Patent JP2006515563
Kind Code:
A
Abstract:
Compounds of formula (I) cyclo [NX1-R1-CO-NX2-R2-CO-NX3-R3-CO-NX4-CO-NX5-R5-CO], wherein at least one x-fluoroalkylated amino acid is present, are inhibitors of integrins, particularly those belonging to the alphavbeta3 and alphavbeta5 family, and thus are useful as medicaments, particularly for the treatment of the underlying diseases responsible for abnormal angiogenesis, such as retinopathy, acute kidney failure, osteoporosis and metastases. The compounds described herein are also useful as diagnostic agents, when appropriately labelled, especially for the detection and location of small tumour masses and arterial occlusion events.
Inventors:
Arma Dar Pozzo
Giuseppe Giannini
Claudio Pisano
Giuseppe Giannini
Claudio Pisano
Application Number:
JP2004524061A
Publication Date:
June 01, 2006
Filing Date:
July 18, 2003
Export Citation:
Assignee:
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE SOCIETA PER AZIONI
International Classes:
C07K7/64; A61K38/00; A61P9/10; A61P9/14; A61P13/12; A61P19/10; A61P27/02; A61P35/00; A61P35/04; A61P43/00; C07K7/54
Foreign References:
| US6127335A | 2000-10-03 | |||
| DE19725368A1 | 1998-12-17 | |||
| US5849692A | 1998-12-15 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Mina Shiga