Title:
損傷した哺乳類神経組織を治療するためのピリジン類
Document Type and Number:
Japanese Patent JP2006515585
Kind Code:
A
Abstract:
The invention provides novel pyridines, pharmaceutical compositions comprising such pyridines, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord, in one embodiment, the compounds, compositions, and methods of the instant invention treat a mammalian nerve tissue injury by restoring action potential or nerve impulse conduction through a nerve tissue lesion. Significantly, in vivo application of compounds of the instant invention established, on the basis of SSEP testing, that the compounds provide longer lasting effects at lower concentrations than comparable treatment with the known agent 4-aminopyridine (4 AP).
Inventors:
Borgens, Richard Bee
Shi, Rii
Byrne, Stephen Earl
Smith, Daniel Tea
Shi, Rii
Byrne, Stephen Earl
Smith, Daniel Tea
Application Number:
JP2004559375A
Publication Date:
June 01, 2006
Filing Date:
December 05, 2003
Export Citation:
Assignee:
PURDUE RESEARCH FOUNDATION
International Classes:
C07D213/74; A61K31/437; A61K31/4409; A61K31/675; A61P17/02; A61P19/00; A61P25/00; A61P31/00; A61P35/00; A61P43/00; C07D213/02; C07D213/75; C07D471/04
Domestic Patent References:
| JPH08504772A | 1996-05-21 | |||
| JPH08505044A | 1996-06-04 | |||
| JPS57114570A | 1982-07-16 | |||
| JPH022327A | 1990-01-08 | |||
| JP2002540206A | 2002-11-26 | |||
| JP2002513425A | 2002-05-08 | |||
| JP2003073357A | 2003-03-12 |
Foreign References:
| US3433873A | 1969-03-18 | |||
| US3786058A | 1974-01-15 | |||
| SU464177A1 | 1978-03-25 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Ken Matsumoto