Title:
癌の治療効果増進のための抗癌剤と修飾多糖体の併用
Document Type and Number:
Japanese Patent JP2006515647
Kind Code:
A
Abstract:
Modified polysaccharide compositions and their use in combination with at least one anti-cancer drug for treating subjects with cancer, reduce toxicity and inhibit metastasis, are described. The modified polysaccharide includes a saccharide backbone being less than 5% esterified and containing repeating units, wherein each repeating unit has a plurality of uronic acid molecules, each repeating unit having at least one neutral monosaccharide attached thereto, at least one side chain of saccharides attached to the backbone further comprising a plurality of neutral saccharides or saccharide derivatives; and having an average molecule weight in the range of 15 to 60 kD. The polysaccharide when combine with the chemotherapeutic drug behave as a delivery vehicle, which positively enhance the chemotherapeutic effect while reducing side effects.
Inventors:
Pratt, David
Application Number:
JP2006500921A
Publication Date:
June 01, 2006
Filing Date:
January 14, 2004
Export Citation:
Assignee:
Pro-Pharmaceuticals, Inc.
International Classes:
C08B37/00; A61K31/337; A61K31/513; A61K31/715; A61K45/06; A61K47/36; A61P35/00; A61K
Attorney, Agent or Firm:
Takenori Hiroe
Takanobu Takekawa
High Shinichi Ara
Nakamura Shigenori
Tsutomu Nishio
Takanobu Takekawa
High Shinichi Ara
Nakamura Shigenori
Tsutomu Nishio