Title:
バイオマーカープロファイルを用いる敗血症またはSIRSの診断
Document Type and Number:
Japanese Patent JP2006515670
Kind Code:
A
Abstract:
The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population that develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated from the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms of sepsis. Further, because the biomarker expression is assayed for its profile, identification of the particular biomarkers is unnecessary. The comparison of an individual's biomarker profile to biomarker profiles of appropriate reference populations likewise can be used to diagnose SIRS in the individual.
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Inventors:
Richard Ivy
Gentle, Thomas
Moore, richard
Towns, michael
Batuul, Nicholas
Robert Rosenstein
Nadew, germs
Golden baum, paul
Shi Son
Copalino, donald
James Garrett
Tice, Gregory
Gentle, Thomas
Moore, richard
Towns, michael
Batuul, Nicholas
Robert Rosenstein
Nadew, germs
Golden baum, paul
Shi Son
Copalino, donald
James Garrett
Tice, Gregory
Application Number:
JP2004552103A
Publication Date:
June 01, 2006
Filing Date:
November 12, 2003
Export Citation:
Assignee:
Becton, Dickinson and Company
International Classes:
G01N33/53; C12Q1/68; G01N27/62; G01N33/483; G01N33/68; G01N37/00
Domestic Patent References:
| JPH10332638A | 1998-12-18 | |||
| JPH09508465A | 1997-08-26 | |||
| JPH08511864A | 1996-12-10 |
Other References:
JPN6009025793, ＳＴＥＰＨＡＮ ＨＡＲＢＡＲＴＨ ｅｔ ａｌ．, "Ｄｉａｇｎｏｓｔｉｃ Ｖａｌｕｅ ｏｆ Ｐｒｏｃａｌｃｉｔｏｎｉｎ， Ｉｎｔｅｒｌｅｕｋｉｎ−６， ａｎｄ Ｉｎｔｅｒｌｅｕｋｉｎ−８ ｉｎ Ｃｒｉｔｉｃａｌｌｙ Ｉｌｌ Ｐａｔｉｅｎｔｓ Ａｄｍｉｔ", Ａｍｅｒｉｃａｎ Ｊｏｕｒｎａｌ ｏｆ Ｒｅｓｐｉｒａｔｏｒｙ ａｎｄ Ｃｒｉｔｉｃａｌ Ｃａｒｅ Ｍｅｄｉｃｉｎｅ, 200108, １６４, ３９６ − ４０２
JPN6009025794, Ａｎｎｉｋａ ＴＡＫＡＬＡ ｅｔ ａｌ．, "Ｓｙｓｔｅｍｉｃ ｉｎ￣ａｍｍａｔｏｒｙ ｒｅｓｐｏｎｓｅ ｓｙｎｄｒｏｍｅｗｉｔｈｏｕｔ ｓｙｓｔｅｍｉｃ ｉｎ￣ａｍｍａｔｉｏｎ ｉｎ ａｃｕｔｅｌｙｉｌｌ ｐａｔｉｅｎｔｓ ａｄｍｉｔｔｅｄ", Ｃｌｉｎｉｃａｌ Ｓｃｉｅｎｃｅ, 1999, ９６, ２８７−２９５
JPN6009025794, Ａｎｎｉｋａ ＴＡＫＡＬＡ ｅｔ ａｌ．, "Ｓｙｓｔｅｍｉｃ ｉｎ￣ａｍｍａｔｏｒｙ ｒｅｓｐｏｎｓｅ ｓｙｎｄｒｏｍｅｗｉｔｈｏｕｔ ｓｙｓｔｅｍｉｃ ｉｎ￣ａｍｍａｔｉｏｎ ｉｎ ａｃｕｔｅｌｙｉｌｌ ｐａｔｉｅｎｔｓ ａｄｍｉｔｔｅｄ", Ｃｌｉｎｉｃａｌ Ｓｃｉｅｎｃｅ, 1999, ９６, ２８７−２９５
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Natsuo Tanaka