Title:
WISP活性を調節し検出するための方法及び組成物
Document Type and Number:
Japanese Patent JP2006516956
Kind Code:
A
Abstract:
Methods and compositions for use in modulating the activity(s) of WISP-1 polypeptide are provided. WISP-1 antagonists include anti-WISP-1 antibodies, WISP-1 immunoadhesins and WISP-1 variants (and fusion proteins thereof) which inhibit or neutralize induction or secretion of IIAS2, IIA, CD44 or RIIAMM by native human WISP-1 polypeptide in at least one type of cells or pathological conditions associated with native WISP-1 polypeptides.
Inventors:
Denoye, rucksack
Phil Barroff, Ellen
Phil Barroff, Ellen
Application Number:
JP2004549836A
Publication Date:
July 13, 2006
Filing Date:
June 28, 2003
Export Citation:
Assignee:
GENENTECH,INC.
International Classes:
C07K16/22; A61K39/395; A61K45/00; A61P1/00; A61P11/00; A61P15/00; A61P25/00; A61P35/00; C07K14/47; C07K16/30; C07K19/00; C12N15/09; A61K39/00; C07K14/475; C12P21/08
Foreign References:
| WO1999021998A1 | 1999-05-06 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori