Title:
超臨界流体を用いた組み合わせ薬学的処方物を調製するためのプロセス
Document Type and Number:
Japanese Patent JP2006516958
Kind Code:
A
Abstract:
The invention is directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) contacting two or more active pharmaceutical ingredients with a supercritical fluid to form a supercritical fluid solution; and (b) separating the active ingredients from the supercritical solution to yield a powder precipitate. Preferably, the pharmaceutical formulation prepared according to the invention contains a combination of two anti-infective agents or two anticancer agents. The invention is further directed to a process for preparing a pharmaceutical formulation containing two or more active pharmaceutical ingredients comprising: (a) combining two or more active ingredients with a cosolvent to form a solution; (b) contacting the solution with a supercritical fluid; and (c) recovering the precipitate in a powder form.
Inventors:
Pajavar, Satish
Puri, Nabunito
Musuku Malang, Poonganlan
Chordia, Lalit
Puri, Nabunito
Musuku Malang, Poonganlan
Chordia, Lalit
Application Number:
JP2004562314A
Publication Date:
July 13, 2006
Filing Date:
December 19, 2003
Export Citation:
Assignee:
BAXTER INTERNATIONAL INCORP0RATED
International Classes:
A61K9/14; A61K9/16; A61K31/337; A61K31/43; A61K31/7048; A61K45/06; A61P31/04; A61P35/00; A61P43/00; B01J3/00
Domestic Patent References:
| JP2002530318A | 2002-09-17 | |||
| JPH024439A | 1990-01-09 |
Foreign References:
| WO2001003821A1 | 2001-01-18 | |||
| WO2002058674A2 | 2002-08-01 | |||
| WO2002093132A2 | 2002-11-21 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita