Title:
ヘテロ置換ナトリウムチャネル遮断薬
Document Type and Number:
Japanese Patent JP2006518389
Kind Code:
A
Abstract:
The present invention relates to group of butylphenyl-pyrazinoylguanidine compounds useful as sodium channel blockers. The compounds may be used to promote promoting hydration of mucosal surfaces.
More Like This:
| WO/2006/003329 | COLLECTION OF TRACEABLE COMPOUNDS AND USES THEREOF |
| WO/2011/118672 | PLASMA KALLIKREIN INHIBITOR |
| JPS56158771 | NOVEL HETEROCYCLIC SUBSTITUTED PYRADINOYLGUANIDINE AND ITS MANUFACTURE |
Inventors:
Michael Earl Johnson
Application Number:
JP2006503605A
Publication Date:
August 10, 2006
Filing Date:
February 18, 2004
Export Citation:
Assignee:
Parion Sciences, Inc.
International Classes:
C07D241/26; A61K31/4965; A61P1/00; A61P1/02; A61P1/10; A61P7/10; A61P9/12; A61P9/14; A61P11/00; A61P11/02; A61P11/06; A61P15/02; A61P17/00; A61P27/02; A61P27/16; A61P29/00; A61P37/02; A61P43/00; C07D405/12; C07D405/14
Domestic Patent References:
| JPS426249B1 | ||||
| JPS438470B1 | ||||
| JPS4214556B1 | ||||
| JPS452592B1 | ||||
| JP2005530692A | 2005-10-13 |
Foreign References:
| WO2001005773A1 | 2001-01-25 | |||
| US3573306A | 1971-03-30 |
Other References:
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JPN7009004379, ＢＡＲＢＲＹ， Ｐ． ｅｔ ａｌ, "Ｂｉｏｃｈｅｍｉｃａｌ ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ｔｗｏ ｔｙｐｅｓ ｏｆ ｐｈｅｎａｍｉｌ ｂｉｎｄｉｎｇ ｓｉｔｅｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ａｍｉｌｏｒｉｄｅ−ｓｅｎｓｉｔｉｖ", ＢＩＯＣＨＥＭＩＳＴＲＹ, 1989, ｖｏｌ． ２８， ｎｏ． ９, ｐ．３７４４−３７４９
JPN7009004380, ＢＡＲＢＲＹ， Ｐ． ｅｔ ａｌ, "［３Ｈ］Ｐｈｅｎａｍｉｌ ｂｉｎｄｉｎｇ ｐｒｏｔｅｉｎ ｏｆ ｔｈｅ ｒｅｎａｌ ｅｐｉｔｈｅｌｉｕｍ Ｎａ＋ ｃｈａｎｎｅｌ． Ｐｕｒｉｆｉｃａｔｉｏｎ， ａｆｆｉｎｉｔｙ ｌａｂｅｌｉｎｇ， ａ", ＢＩＯＣＨＥＭＩＳＴＲＹ, 1990, ｖｏｌ． ２９， ｎｏ． ４, ｐ．１０３９−１０４５
JPN7009004381, ＶＥＬＬＹ， Ｊ． ｅｔ ａｌ, "Ｅｆｆｅｃｔｓ ｏｆ ａｍｉｌｏｒｉｄｅ ａｎｄ ｉｔｓ ａｎａｌｏｇｕｅｓ ｏｎ ［３ｈ］ｂａｔｒａｃｈｏｔｏｘｉｎｉｎ−Ａ ２０−α ｂｅｎｚｏａｔｅ ｂｉｎｄｉｎｇ， ［３Ｈ］ｔｅｔｒａｃａｉ", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＯＬＯＧＹ, 1988, ｖｏｌ． １４９， ｎｏ． １−２, ｐ．９７−１０５
JPN7009004382, ＫＬＥＹＭＡＮ， Ｔ． Ｒ． ｅｔ ａｌ, "Ｔｈｅ ｃｅｌｌｕｌａｒ ｐｏｏｌ ｏｆ Ｎａ＋ ｃｈａｎｎｅｌｓ ｉｎ ｔｈｅ ａｍｐｈｉｂｉａｎ ｃｅｌｌ ｌｉｎｅ Ａ６ ｉｓ ｎｏｔ ａｌｔｅｒｅｄ ｂｙ Ｍｉｎｅｒａｌｃｏｒｔｉｃｏｉｄｓ", ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 198908, ｖｏｌ． ２６４， ｎｏ． ２０, ｐ．１１９９５−１２０００
JPN5004010360, ＥＰＡＮＤ, ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, 1991, Ｖ６３ Ｎ２, Ｐ２４７−２５１
JPN5004010359, ＢＩＣＫＩＮＧ, Ｊ．ＭＥＤ．ＣＨＥＭ．, 1965, Ｖ８ Ｎ５, Ｐ６３８−６４２
JPN7009004379, ＢＡＲＢＲＹ， Ｐ． ｅｔ ａｌ, "Ｂｉｏｃｈｅｍｉｃａｌ ｉｄｅｎｔｉｆｉｃａｔｉｏｎ ｏｆ ｔｗｏ ｔｙｐｅｓ ｏｆ ｐｈｅｎａｍｉｌ ｂｉｎｄｉｎｇ ｓｉｔｅｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ａｍｉｌｏｒｉｄｅ−ｓｅｎｓｉｔｉｖ", ＢＩＯＣＨＥＭＩＳＴＲＹ, 1989, ｖｏｌ． ２８， ｎｏ． ９, ｐ．３７４４−３７４９
JPN7009004380, ＢＡＲＢＲＹ， Ｐ． ｅｔ ａｌ, "［３Ｈ］Ｐｈｅｎａｍｉｌ ｂｉｎｄｉｎｇ ｐｒｏｔｅｉｎ ｏｆ ｔｈｅ ｒｅｎａｌ ｅｐｉｔｈｅｌｉｕｍ Ｎａ＋ ｃｈａｎｎｅｌ． Ｐｕｒｉｆｉｃａｔｉｏｎ， ａｆｆｉｎｉｔｙ ｌａｂｅｌｉｎｇ， ａ", ＢＩＯＣＨＥＭＩＳＴＲＹ, 1990, ｖｏｌ． ２９， ｎｏ． ４, ｐ．１０３９−１０４５
JPN7009004381, ＶＥＬＬＹ， Ｊ． ｅｔ ａｌ, "Ｅｆｆｅｃｔｓ ｏｆ ａｍｉｌｏｒｉｄｅ ａｎｄ ｉｔｓ ａｎａｌｏｇｕｅｓ ｏｎ ［３ｈ］ｂａｔｒａｃｈｏｔｏｘｉｎｉｎ−Ａ ２０−α ｂｅｎｚｏａｔｅ ｂｉｎｄｉｎｇ， ［３Ｈ］ｔｅｔｒａｃａｉ", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＡＲＭＡＣＯＬＯＧＹ, 1988, ｖｏｌ． １４９， ｎｏ． １−２, ｐ．９７−１０５
JPN7009004382, ＫＬＥＹＭＡＮ， Ｔ． Ｒ． ｅｔ ａｌ, "Ｔｈｅ ｃｅｌｌｕｌａｒ ｐｏｏｌ ｏｆ Ｎａ＋ ｃｈａｎｎｅｌｓ ｉｎ ｔｈｅ ａｍｐｈｉｂｉａｎ ｃｅｌｌ ｌｉｎｅ Ａ６ ｉｓ ｎｏｔ ａｌｔｅｒｅｄ ｂｙ Ｍｉｎｅｒａｌｃｏｒｔｉｃｏｉｄｓ", ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 198908, ｖｏｌ． ２６４， ｎｏ． ２０, ｐ．１１９９５−１２０００
JPN5004010360, ＥＰＡＮＤ, ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＡＮＣＥＲ, 1991, Ｖ６３ Ｎ２, Ｐ２４７−２５１
JPN5004010359, ＢＩＣＫＩＮＧ, Ｊ．ＭＥＤ．ＣＨＥＭ．, 1965, Ｖ８ Ｎ５, Ｐ６３８−６４２
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro