Title:
アデノシン受容体アゴニストの治療上の使用
Document Type and Number:
Japanese Patent JP2006519824
Kind Code:
A
Abstract:
Compounds of the class of adenosines, represented by structural formula I, wherein R is C1-4 alkoxy, and X is H or OH, are useful in a method of preventing, treating, or ameliorating various conditions or disorders, e.g., inflammation, which comprises administering a compound of formula I to a subject in need of such prevention, treatment, or amelioration, for example, at a dosage which gives rise to a peak plasma concentration in the subject that is less than the EC50 value of the compound at adenosine receptors at pH 7.4.
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Inventors:
Peter Richardson
Application Number:
JP2006505924A
Publication Date:
August 31, 2006
Filing Date:
March 05, 2004
Export Citation:
Assignee:
Cambridge Biotechnology Ltd.
International Classes:
A61K31/7076; A61P1/04; A61P7/00; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P17/02; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/02; A61P25/08; A61P25/28; A61P29/00; A61P29/02; A61P31/04; A61P31/18; A61P33/06; A61P35/00; A61P37/04; A61P37/06; A61P39/02; A61P43/00; C07H19/167; C07H19/173
Domestic Patent References:
| JP2002500188A | 2002-01-08 |
Foreign References:
| US5877180A | 1999-03-02 | |||
| US5877180A | 1999-03-02 |
Other References:
JPN6010060446, Ｊ． Ｍｅｄ． Ｃｈｅｍ．, 1991, ３４, １３３４−１３３９
JPN5006003902, ＲＩＥＧＥＲ Ｊ Ｍ, ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ, 2001, Ｖ４４, Ｐ５３１−５３９, US, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN5006003902, ＲＩＥＧＥＲ Ｊ Ｍ, ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ, 2001, Ｖ４４, Ｐ５３１−５３９, US, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
Attorney, Agent or Firm:
Mitsuo Tanaka
Tadayuki Motoyama
Kenji Tomita
Tadayuki Motoyama
Kenji Tomita