Title:
トランスフォーミング成長因子(TGF)阻害剤としてのピラジン化合物
Document Type and Number:
Japanese Patent JP2006519833
Kind Code:
A
Abstract:
Novel pyrazine compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-beta signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Inventors:
Manchev, Michael John
Application Number:
JP2006506288A
Publication Date:
August 31, 2006
Filing Date:
February 23, 2004
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D241/28; A61K31/4965; A61K31/497; A61K31/50; A61K31/501; A61K31/5377; A61K31/55; A61P1/16; A61P9/08; A61P11/00; A61P13/12; A61P17/00; A61P35/00; A61P43/00; C07D241/26; C07D401/04; C07D401/12; C07D403/12; C07D405/04; C07D405/14; C07D409/04; C07D409/14
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
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