Title:
ヌクレオチド・ワクチン組成、ヌクレオチド及び細胞ワクチン組成の産出方法、ワクチン組成、ワクチン組成使用、免疫反応産出方法、疾患の治療または予防方法、抗原提示細胞から成るキット
Document Type and Number:
Japanese Patent JP2006523688
Kind Code:
A
Abstract:
A method of treating a Philadelphia chromosome-positive tumor in a subject comprises administering to the subject a therapeutic composition comprising an incubated combined mixture of (a) a first component comprising (i) Philadelphia chromosome-positive tumor lysate, (ii) plasmid encoding bcr/abl fusion protein, or (iii) bcr/abl fusion peptide; and (b) a second component comprising plasmacytoid dendritic cells expressing Toll-like receptor 9 and modified for stable expression of CD40 ligand or GM-CSF by a nucleotide sequence engineered into said plasmacytoid dendritic cells.
Inventors:
Maren Juan
Application Number:
JP2006508023A
Publication Date:
October 19, 2006
Filing Date:
April 14, 2004
Export Citation:
Assignee:
Maren Juan
International Classes:
A61K38/08; A61K39/00; A61K9/127; A61K35/12; A61K35/14; A61K35/28; A61K35/76; A61K38/21; A61P3/10; A61P7/00; A61P29/00; A61P31/04; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08
Domestic Patent References:
| JP2003506095A | 2003-02-18 |
Foreign References:
| WO2001083785A2 | 2001-11-08 |
Attorney, Agent or Firm:
Naoki Yoshimura
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