Title:
トロンビンの過剰形成及び/又はトロンビンレセプターの発現上昇により生じる血栓塞栓性疾病及び疾患の治療及び予防のためのジピリダモール又はモピダモールの使用
Document Type and Number:
Japanese Patent JP2006524203
Kind Code:
A
Abstract:
A method of treatment of the human or non-human animal body for treating or preventing disorders caused by elevated thrombin or elevated thrombin receptor expression is disclosed, for example thromboembolic disease vascular syndromes, or proliferative diseases, which method comprises administering to a human or non-human animal body in need of such treatment an effective amount of a pharmaceutical composition containing dipyridamole, mopidamole or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions as well as the use of dipyridamole or mopidamole for the manufacture of these pharmaceutical compositions.
Inventors:
Iselt Wolfgang
Sable Annie Victor El
Sable Annie Victor El
Application Number:
JP2006505175A
Publication Date:
October 26, 2006
Filing Date:
April 17, 2004
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
A61K31/5025; A61K31/519; A61K45/00; A61K45/06; A61P7/02; A61P9/00
Domestic Patent References:
| JPS6348219A | 1988-02-29 | |||
| JP2003512431A | 2003-04-02 | |||
| JP2001509815A | 2001-07-24 |
Foreign References:
| WO2003007846A1 | 2003-01-30 |
Other References:
MALININ ALEX I, HEARTDRUG, vol. V2 N2, JPN5006003303, March 2002 (2002-03-01), pages 93 - 104, ISSN: 0001729152
MAS J L, ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX, vol. V95 N.SPEC.7, JPN5006003305, November 2002 (2002-11-01), pages 53 - 57, ISSN: 0001729153
GOEL, CLINICAL CANCER RESEARCH, vol. V7, JPN5006006608, January 2001 (2001-01-01), pages 175 - 184, ISSN: 0001729154
JAHN U R, ANESTHESIA AND ANALGESIA, vol. V94 N.2S SUPPLEMENT, JPN5006003304, February 2002 (2002-02-01), pages 96, ISSN: 0001729155
DAVID MASSEL ET AL.: "Risks and benefits of adding anti-platelet therapy to warfarin among patients with prosthetic heart", J AM COLL CARDIOL, vol. 37, no. 2, JPN6010053111, 2001, pages 569 - 578, XP001182552, ISSN: 0001729156, DOI: 10.1016/S0735-1097(00)01135-9
CAPPELLERI JC ET AL.: "Efficacy and safety of combined anticoagulant and antiplatelet therapy versus anticoagulant monother", AM HEART J., vol. Vol. 130, No. 3, Part 1, JPN6010053112, September 1995 (1995-09-01), pages 547 - 552, ISSN: 0001729157
GUSUTAFSSON, D. ET AL: "The Direct Thrombin Inhibitor Melagatran and its Oral Prodrug H 376/95: Intestinal Absorption Proper", THROMB. RES., vol. 101, no. 3, JPN6011054215, 2001, pages 171 - 181, XP001197148, ISSN: 0002043607, DOI: 10.1016/S0049-3848(00)00399-6
MAS J L, ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX, vol. V95 N.SPEC.7, JPN5006003305, November 2002 (2002-11-01), pages 53 - 57, ISSN: 0001729153
GOEL, CLINICAL CANCER RESEARCH, vol. V7, JPN5006006608, January 2001 (2001-01-01), pages 175 - 184, ISSN: 0001729154
JAHN U R, ANESTHESIA AND ANALGESIA, vol. V94 N.2S SUPPLEMENT, JPN5006003304, February 2002 (2002-02-01), pages 96, ISSN: 0001729155
DAVID MASSEL ET AL.: "Risks and benefits of adding anti-platelet therapy to warfarin among patients with prosthetic heart", J AM COLL CARDIOL, vol. 37, no. 2, JPN6010053111, 2001, pages 569 - 578, XP001182552, ISSN: 0001729156, DOI: 10.1016/S0735-1097(00)01135-9
CAPPELLERI JC ET AL.: "Efficacy and safety of combined anticoagulant and antiplatelet therapy versus anticoagulant monother", AM HEART J., vol. Vol. 130, No. 3, Part 1, JPN6010053112, September 1995 (1995-09-01), pages 547 - 552, ISSN: 0001729157
GUSUTAFSSON, D. ET AL: "The Direct Thrombin Inhibitor Melagatran and its Oral Prodrug H 376/95: Intestinal Absorption Proper", THROMB. RES., vol. 101, no. 3, JPN6011054215, 2001, pages 171 - 181, XP001197148, ISSN: 0002043607, DOI: 10.1016/S0049-3848(00)00399-6
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama