Title:
心室収縮状態を評価する方法及び装置
Document Type and Number:
Japanese Patent JP2006525086
Kind Code:
A
Abstract:
Methods and devices for improving ventricular contractile status of a patient suitably exploit changes in ventricular pressure and/or dP/dtmax to provide and/or optimize a response to a patient. The ventricular pressure may be appropriately correlated to intracellular calcium regulation, which is indicative of contractile status. To assess ventricular contractile status, the device suitably observes a cardiac perturbation of the patient and measures force interval potentiation following the perturbation. The contractile potentiation can then be stored and/or quantified in the implantable medical device to determine the ventricular contractile status of the patient, and an appropriate response may be provided to the patient as a function of the ventricular contractile status. Examples of responses may include administration of drug or neuro therapies, modification of a pacing rate, or the like. Force interval potentiation may also be used to optimize or improve a parameter for a response provided by the implantable medical device.
Inventors:
Lawrence Jay, Mulligan
Gebhard, Ursula
Gebhard, Ursula
Application Number:
JP2006513393A
Publication Date:
November 09, 2006
Filing Date:
April 28, 2004
Export Citation:
Assignee:
Medtronic Incorporated
International Classes:
A61B5/0215; A61N1/05; A61N1/362; A61N1/365
Domestic Patent References:
| JP2004523269A | 2004-08-05 | |||
| JPH07542A | 1995-01-06 | |||
| JPH06506619A | 1994-07-28 |
Foreign References:
| WO2002053026A2 | 2002-07-11 | |||
| WO2002053228A1 | 2002-07-11 | |||
| US20020151938A1 | 2002-10-17 |
Other References:
JPN6010020826, 橋本敬太郎, "”心筋カルシウムシグナリング−その整理学的，病態学的意義について−”", Ｔｈｅｒａｐｅｕｔｉｃ Ｒｅｓｅａｒｃｈ ｖｏｌ．１７，ｎｏ．１２, 1996, ４６２３〜４６３５頁
JPN6010020829, ＹＯＮＡ ＭＡＨＬＥＲ ａｎｄ ＳＨＬＯＭＯ ＲＯＧＥＬ, "”ＱＵＡＮＴＩＴＡＴＩＶＥ ＡＮＡＬＹＳＩＳ ＯＦ ＭＹＯＣＡＲＤＩＡＬ ＦＯＲＣＥ ＡＮＤ ＣＯＮＴＲＡＣＴＩＬＥ ＳＴＡＴＥ ＩＮ ＶＩＶＯ ＲＡＴＥ ＡＮＤ ＲＨＹＴＨＭ ＤＩＳＴＵＲＢＡＮＣＥ", Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｍｅｃｈａｎｉｃｓ Ｖｏｌ．１４，Ｎｏ．２, 19810306, ｐｐ．９９−１０９
JPN6010020829, ＹＯＮＡ ＭＡＨＬＥＲ ａｎｄ ＳＨＬＯＭＯ ＲＯＧＥＬ, "”ＱＵＡＮＴＩＴＡＴＩＶＥ ＡＮＡＬＹＳＩＳ ＯＦ ＭＹＯＣＡＲＤＩＡＬ ＦＯＲＣＥ ＡＮＤ ＣＯＮＴＲＡＣＴＩＬＥ ＳＴＡＴＥ ＩＮ ＶＩＶＯ ＲＡＴＥ ＡＮＤ ＲＨＹＴＨＭ ＤＩＳＴＵＲＢＡＮＣＥ", Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｍｅｃｈａｎｉｃｓ Ｖｏｌ．１４，Ｎｏ．２, 19810306, ｐｐ．９９−１０９
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita