Title:
免疫応答を減少させる方法
Document Type and Number:
Japanese Patent JP2006525371
Kind Code:
A
Abstract:
The invention relates to methods of reducing an immune response to a transgene product in a mammal by co-administration of a small-interfering ribonucleic acid (siRNA) molecule that temporarily inhibits or reduces transgene expression, wherein the siRNA is administered in an amount, and for a period of time, sufficient to reduce an immune response to the transgene product when it is expressed at therapeutic levels. The present invention further relates to methods of administering siRNAs to a mammal to reduce an immune response to an immunogenic protein, such as an enzyme used in enzyme replacement therapy.
Inventors:
Chu Kiming
Application Number:
JP2006514307A
Publication Date:
November 09, 2006
Filing Date:
May 05, 2004
Export Citation:
Assignee:
Genzyme Corporation
International Classes:
A61K48/00; A61P3/00; A61P43/00; C12N15/11; C12N15/113; C12N15/09; A61K
Other References:
JPN6010039852, Ｔｒａｎｓｇｅｎｉｃ Ｒｅｓｅａｒｃｈ, 2003, Ｖｏｌ．１２, ｐ．１７１−１７８
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi
Previous Patent: 活性物質要素および該活性物質レイヤーの遠位に副作用物質要素を含む耐...
Next Patent: アリールアニリンβ−２アドレナリン作用性レセプタアゴニストおよびコ...
Next Patent: アリールアニリンβ−２アドレナリン作用性レセプタアゴニストおよびコ...