ジアゼパムを含有する経鼻マイクロエマルジョン

Japanese Patent JP2006527764

A

Diazepam is administered intranasally in the form of specific microemulsions having advantageous properties. The microemulsions are comprised of about equal quantities of a fatty acid and water with the remainder being a hydrophilic surfactant, a polar solvent and an alcohol in a weight ratio such that alcohol is present in a greater quantity by weight than either of the other two. Nasal administration of the subject microemulsions produces a high plasma concentration of diazepam nearly as fast as intravenous administration. The present microemulsions are particularly suitable for a prompt and timely treatment of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

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Choi Yeon-Moon
Kim Won-Ho

JP2006516926A

December 07, 2006

June 15, 2004

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SK Corporation

A61K31/5513; A61K9/00; A61K9/107; A61K9/14; A61K9/70; A61K47/10; A61K47/14; A61K47/26; A61K47/34; A61P25/00; A61P25/08; A61P25/10; A61P25/12

JP2003505403A

2003-02-12

JPN6010059605; ＬＩ，Ｌ．　ｅｔ　ａｌ: 'Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　ａｎ　ｅｔｈｙｌ　ｌａｕｒａｔｅ-ｂａｓｅｄ　ｍｉｃｒｏｅｍｕｌｓｉｏｎ　ｆｏｒ　ｒａｐｉｄ-ｏｎｓｅｔ　ｉｎｔｒａｎａｓａｌ　ｄｅｌｉｖｅｒｙ　ｏｆ　ｄｉａｚｅｐａｍ' Ｉｎｔｅｒｎａｔｉｏｎａｌ　ｊｏｕｒｎａｌ　ｏｆ　ｐｈａｒｍａｃｅｕｔｉｃｓ Ｖｏｌ．２３７，　Ｎｏ．１-２, 2002, ｐ．７７-８５
JPN6010059605; ＬＩ，Ｌ．　ｅｔ　ａｌ: 'Ｄｅｖｅｌｏｐｍｅｎｔ　ｏｆ　ａｎ　ｅｔｈｙｌ　ｌａｕｒａｔｅ-ｂａｓｅｄ　ｍｉｃｒｏｅｍｕｌｓｉｏｎ　ｆｏｒ　ｒａｐｉｄ-ｏｎｓｅｔ　ｉｎｔｒａｎａｓａｌ　ｄｅｌｉｖｅｒｙ　ｏｆ　ｄｉａｚｅｐａｍ' Ｉｎｔｅｒｎａｔｉｏｎａｌ　ｊｏｕｒｎａｌ　ｏｆ　ｐｈａｒｍａｃｅｕｔｉｃｓ Ｖｏｌ．２３７，　Ｎｏ．１-２, 2002, ｐ．７７-８５

Calyx
Miyazaki Yoshio
Mitsuo Tateishi
Toshio Nakamura
Tsutomu Kato
Kaoru Onozuka
High Masahiro
Yusuke Murakoshi

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