Title:
プテリジン誘導体の免疫抑制効果
Document Type and Number:
Japanese Patent JP2006528224
Kind Code:
A
Abstract:
Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.
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Inventors:
War, Marc Josef Albert
Heldewine, Pete Andre Mauritz Maria
Pfreiderer, Wolfgang Eugen
Heldewine, Pete Andre Mauritz Maria
Pfreiderer, Wolfgang Eugen
Application Number:
JP2006529892A
Publication Date:
December 14, 2006
Filing Date:
May 21, 2004
Export Citation:
Assignee:
4 AZA BIOSCIENCE NV
International Classes:
C07D475/02; A61K31/505; A61K31/52; A61K31/535; A61K31/5377; A61K31/57; A61K38/13; A61P9/00; A61P25/00; A61P35/00; A61P37/02; A61P37/06
Attorney, Agent or Firm:
Kuro Fukami
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai