Title:
第Xa因子阻害剤としてのインドール誘導体
Document Type and Number:
Japanese Patent JP2006528940
Kind Code:
A
Abstract:
The present invention relates to compounds of the formula I, in which R<0> ; R<1> ; R<2> ; R<3> ; R<4> ; R<5> ; R<6> ; R<7> ; Q; V, G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
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Inventors:
Marc Nazareth
Volkmar Weener
Kurt Ritter
Volker Lux
Volkmar Weener
Kurt Ritter
Volker Lux
Application Number:
JP2006529740A
Publication Date:
December 28, 2006
Filing Date:
May 05, 2004
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07D401/14; A61K31/454; A61K31/4545; A61K31/553; A61P7/02; A61P9/00; A61P9/10; A61P29/00; A61P43/00; C07D413/14; C07D473/02; C07D475/02; C07D487/02
Domestic Patent References:
| JP2001527066A | 2001-12-25 | |||
| JP2005514365A | 2005-05-19 | |||
| JP2001527066A | 2001-12-25 | |||
| JP2005514365A | 2005-05-19 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa