Title:
置換3-アルキルおよび3-アルケニルアゼチジン誘導体
Document Type and Number:
Japanese Patent JP2007500246
Kind Code:
A
Abstract:
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
Inventors:
Baker, Robert Kay
Yurt, jiang ming
Miyao, Xiu
Ruprecht, Kathaleen M
Yurt, jiang ming
Miyao, Xiu
Ruprecht, Kathaleen M
Application Number:
JP2006533655A
Publication Date:
January 11, 2007
Filing Date:
June 09, 2004
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D205/04; A61K31/381; A61K31/397; A61K31/4178; A61K31/4196; A61K31/4427; A61K31/695; A61P1/00; A61P1/10; A61P1/16; A61P3/04; A61P9/00; A61P11/06; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/22; A61P25/30; A61P43/00; C07D205/06; C07D401/06; C07D403/06; C07D403/10; C07D409/06
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura