Title:
副作用が低減されたトラネキサム酸製剤
Document Type and Number:
Japanese Patent JP2007500699
Kind Code:
A
Abstract:
Tranexamic acid formulated in an oral dosage form with at least one agent that decreases tranexamic acid release in the stomach. Such formulations minimize nausea, vomiting, and other adverse gastric effects that may accompany tranexamic acid therapy, for example, to treat heavy menstrual bleeding. One embodiment is an extended release formulation with waxes, polymers, etc. that prevent a bolus release of tranexamic acid in the stomach. An alternative embodiment is a delayed release formulation with polymers that prevent release of tranexamic acid in the acid environment of the stomach and delay its release until the formulation reaches the less acid environment of the intestines. Such formulations enhance patient compliance with therapy because adverse effects of tranexamic acid therapy are reduced.
More Like This:
| WO/2000/076478 | CONTROLLED RELEASE AND TASTE MASKING ORAL PHARMACEUTICAL COMPOSITIONS |
| WO/2022/250085 | AGENT FOR PREVENTING OR AMELIORATING PRURITUS |
| WO/1998/022105 | TABLETTED PREPARATION |
Inventors:
Hazley, Ralph, A.
Moore, Keith, A.
Greive, Jeffrey, S.
Moore, Keith, A.
Greive, Jeffrey, S.
Application Number:
JP2006521917A
Publication Date:
January 18, 2007
Filing Date:
July 21, 2004
Export Citation:
Assignee:
The Nodine Pharmaceuticals, Incorporated
International Classes:
A61K31/195; A61K9/20; A61K9/22; A61K47/32; A61K47/38; A61K47/44; A61P1/00; A61P1/06; A61P1/12; A61P15/00
Domestic Patent References:
| JP2002332226A | 2002-11-22 | |||
| JP2001163774A | 2001-06-19 |
Foreign References:
| WO1996019200A1 | 1996-06-27 | |||
| WO2004060364A1 | 2004-07-22 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita