Title:
強力なプロテインキナーゼ阻害剤としての幾何学的に束縛された3-シクロペンチリデン-1,3-ジヒドロインドール-2-オン類
Document Type and Number:
Japanese Patent JP2007501229
Kind Code:
A
Abstract:
The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula: wherein R1-R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases ("PKs"). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
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Inventors:
Chan, Fan-Jie
Twi, Jinron
Way, chun chen
Tan, pen cho
Twi, Jinron
Way, chun chen
Tan, pen cho
Application Number:
JP2006522567A
Publication Date:
January 25, 2007
Filing Date:
August 05, 2004
Export Citation:
Assignee:
Sugen, Incorporated
International Classes:
C07D209/94; A61K31/404; A61K31/405; A61K31/4745; A61P3/10; A61P9/00; A61P9/10; A61P17/06; A61P19/02; A61P19/04; A61P29/00; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07D209/34; C07D209/42; C07D403/04; C07D403/06; C07D403/14; C07D471/02; C07D471/04; C07D
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama