Title:
エピジェネティク・マーカーを使用して組織または細胞タイプを鑑別するための方法および組成物
Document Type and Number:
Japanese Patent JP2007502113
Kind Code:
A
Abstract:
The present invention provides, inter alia, a method for generating a genome-wide epigenomic map, comprising a correlation between methylation variable CpG positions (MVP) and genomic DNA sample types. MVP are those CpG positions that show a variable quantitative level of methylation between sample types. Particular genomic regions of interest (ROI) provide preferred marker sequences that comprise multiple, and preferably proximate MVP, and that have novel utility for distinguishing sample types. The epigenic maps have broad utility, for example, in identifying sample types, or for distinguishing between and among sample types. In a preferred embodiment the epigenomic map is based on methylation variable regions (MVP) within the major histocompatibility complex (MHC), and has utility, for example, in identifying the cell or tissue source of a genomic DNA sample, or for distinguishing one or more particular cell or tissue types among other cell or tissue types. Analysis of epigenetic characteristics of one, or of a set of nucleic acid sequences, in the context of an inventive epigenomic map, allows for the determination of an origin of the nucleic acids.
Inventors:
Levin, Jerun
Berlin, Kurt
Hildman, thomas
Orek, alexander
Beck, stephan
Novic, Karen
Berlin, Kurt
Hildman, thomas
Orek, alexander
Beck, stephan
Novic, Karen
Application Number:
JP2006523343A
Publication Date:
February 08, 2007
Filing Date:
August 12, 2004
Export Citation:
Assignee:
Epigenomics Akchen Gesell shaft
International Classes:
C12N15/09; C12Q1/04; C12Q1/68; G06F19/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama