Title:
特定され選択された電気及び電磁信号を使用したマトリクス・メタロプロテイナーゼ遺伝子発現の制御
Document Type and Number:
Japanese Patent JP2007502693
Kind Code:
A
Abstract:
Methods and devices for the regulation of matrix metalloproteinase gene expression in cartilage cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for reduction of matrix metalloproteinase gene expression and exposing cartilage tissue to the fields generated by specific and selective signals so as to regulate matrix metalloproteinase gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, cartilage defects, and tumor metastasis.
Inventors:
Brighton, curl, tea.
Application Number:
JP2006533804A
Publication Date:
February 15, 2007
Filing Date:
June 14, 2004
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
A61N1/40; A61H39/00; A61K41/00; A61L27/00; A61N1/10; A61N1/32; A61N2/00; A61P11/00; A61P19/02; A61P19/08; A61P29/00; A61P35/04; C12N13/00; A61K
Domestic Patent References:
| JPH02195969A | 1990-08-02 |
Foreign References:
| WO2001062336A1 | 2001-08-30 |
Attorney, Agent or Firm:
Taro Yaguchi
Junichi Omori
Yasuaki Yamaguchi
Junichi Omori
Yasuaki Yamaguchi