Title:
増殖性疾患を治療するためのアデノウイルスベクターとP53遺伝子との組換え体遺伝子医薬
Document Type and Number:
Japanese Patent JP2007504274
Kind Code:
A
Abstract:
A kind of recombinant gene medicine of adenovirus vector and gene p53 which can treat proliferative diseases is a confusion sequence constructed from adenovirus vector and human tumor inhibition gene p53 expression kit. In the present invention, we made homologous recombination of adenovirus vector with human gene p53 in procaryotic cells (E. coli), then obtained the recombinant gene medicine of adenovirus vector and human gene p53 expression kit. The human p53 gene expression kit is a characteristic sequence consisting of promoter-p53 cDNA-polyadenine nucleotide. The medicine can be used to prepare clinic gene therapeutic products for treating proliferative disease such as cheloid.
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Inventors:
Pen, Jaohui
Jean, Shaoji
Jean, Shaoji
Application Number:
JP2006529553A
Publication Date:
March 01, 2007
Filing Date:
May 09, 2004
Export Citation:
Assignee:
Pen, Jaohui
Jean, Shaoji
Jean, Shaoji
International Classes:
A61K38/00; A61K31/711; A61K35/76; A61K48/00; A61P17/00; A61P17/02; A61P35/00; C12N15/12; C12N15/861; C12N15/09
Domestic Patent References:
| JP2001515493A | 2001-09-18 | |||
| JP2001512008A | 2001-08-21 | |||
| JP2001522871A | 2001-11-20 |
Foreign References:
| CN1401778A | 2003-03-12 | |||
| WO1996015245A1 | 1996-05-23 |
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Ryo Hashimoto
Tetsuya Kazama
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Ryo Hashimoto
Tetsuya Kazama