Title:
NEMOオリゴマー化を妨害するように設計されたペプチドによるNF-κB活性化の選択的阻害
Document Type and Number:
Japanese Patent JP2007506422
Kind Code:
A
Abstract:
The present invention relates to polypeptides that inhibit the NF-κB signaling pathway and polynucleotides encoding the same. The present invention further provides methods for the modulation of and/or treatment of inflammatory responses, oncogenesis, viral infection; the regulation of cell proliferation and apoptosis; and regulation of B or T lymphocytes in antigenic stimulation, by administering the polypeptides of the present invention to a subject in need thereof. Finally, the present invention provides a method of identifying polypeptides that modulate oligomerization of NEMO.
Inventors:
Agove, Fabrice
Cortowa, Jill
Aran, Israel
Michelle Veron
Train card, francois
Yamaoka, Shoji
Coic, Eve-Marie
Value, Francois
Cortowa, Jill
Aran, Israel
Michelle Veron
Train card, francois
Yamaoka, Shoji
Coic, Eve-Marie
Value, Francois
Application Number:
JP2006527513A
Publication Date:
March 22, 2007
Filing Date:
September 24, 2004
Export Citation:
Assignee:
INSTITUT PASTEUR
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE(INSERM)
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE(INSERM)
International Classes:
C12N15/09; A61K38/00; A61K39/395; A61P29/00; A61P31/12; A61P35/00; A61P43/00; C07H21/04; C07K14/47; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| JP2002541779A | 2002-12-10 |
Foreign References:
| WO2001083554A2 | 2001-11-08 |
Attorney, Agent or Firm:
Shintaro Nogawa