Title:
テトロドトキシンの安定な凍結乾燥医薬製剤
Document Type and Number:
Japanese Patent JP2007507422
Kind Code:
A
Abstract:
The present invention provides a freeze-dried pharmaceutical formulation comprising tetrodotoxin or an analog thereof in an amount of 0.5-60 µg per dose, which has good stability and is safe for use by injection in humans and can be stored at room temperature for a long time. Said formulation also contains compounds, such as compounds containing glucosidic bonds selected from any one of disaccharides, ficolls, the derivatives thereof or their mixtures capable of reducing C-4 hydroxyl activity of the tetrodotoxin molecule or the analogs thereof, and a co-solvent(s) which improves solubility of tetrodotoxin or the analogs thereof.
Inventors:
Zanxiao
Kang Yu Hong
Juan Xiao Yang
Kang Yu Hong
Juan Xiao Yang
Application Number:
JP2006519747A
Publication Date:
March 29, 2007
Filing Date:
July 02, 2004
Export Citation:
Assignee:
Nannin Maple Leaf Pharmaceutical Company Limited
International Classes:
A61K31/529; A61K9/19; A61K31/70; A61K47/12; A61K47/26; A61K47/36; A61P21/00; A61P25/04; A61P29/00; A61P39/02; A61P43/00
Domestic Patent References:
| JPH09136836A | 1997-05-27 |
Foreign References:
| WO2002041915A1 | 2002-05-30 | |||
| CN1385431A | 2002-12-18 | |||
| WO2001093827A2 | 2001-12-13 | |||
| WO2002022129A1 | 2002-03-21 | |||
| WO1993000807A1 | 1993-01-21 |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama