Title:
アミロイドパシーにおいて、フィブリロジェニックAβペプチドの沈着を改変するために、1-アミノシクロヘキサン誘導体を使用する方法
Document Type and Number:
Japanese Patent JP2007509165
Kind Code:
A
Abstract:
The invention relates to the use of NMDA receptor antagonists such as 1-aminocyclohexane derivatives to modify deposition of potentially toxic and fibrillogenic Abeta peptides in amyloidopathies. Specifically, the invention relates to the ability of memantine to intervene in the processing of APP and decrease the levels of fibrillogenic Abeta peptides.
Inventors:
Gapta Sandeep
Bernardie Pradeep
Rahili Debomoi K.
Farlow Martin Earl.
Bernardie Pradeep
Rahili Debomoi K.
Farlow Martin Earl.
Application Number:
JP2006536825A
Publication Date:
April 12, 2007
Filing Date:
October 22, 2004
Export Citation:
Assignee:
Meltz Pharma Geselsyaft Mito Beschlenktel Haftung und Companion Commande Geselsyaft Auf Akteen
International Classes:
A61K31/13; A61K31/27; A61K31/40; A61K31/445; A61K31/4453; A61K31/473; A61K31/55; A61P25/00; A61P43/00; G01N33/15; G01N33/50; C07D211/32; C07D219/10; C07D295/02; C07D491/06
Attorney, Agent or Firm:
Mitsufumi Esaki
Okumura Yoshimichi
Blacksmith
Okumura Yoshimichi
Blacksmith