Title:
多価エピトープキメラ遺伝子ワクチンの製法
Document Type and Number:
Japanese Patent JP2007509837
Kind Code:
A
Abstract:
The invention relates to a method for preparing polyepitope chimeric gene vaccines, designated as Epitopes Assemble Library Immunization (EALI). It involves the construction of expression libraries of polyepitope chimeric genes with different sizes and lengths using gene shuffling and random assembly so as to screen polyepitope chimeric gene vaccines. Immunization of the body with the gene libraries of the invention results in the induction of high level of specific antibodies and specific types of cytokines, and protection on the body.
Inventors:
Wang Heng
Cai Hi Good
Cai Hi Good
Application Number:
JP2005507345A
Publication Date:
April 19, 2007
Filing Date:
August 01, 2003
Export Citation:
Assignee:
Institute of Basic Medicine, Chinese Academy of Medical Sciences
International Classes:
A61K48/00; A61K39/00; A61K39/015; A61K39/295; A61P31/00; A61P33/06; A61P35/00; A61P37/00; A61P37/02; A61P37/04; C12N15/30; C12N15/09
Attorney, Agent or Firm:
Akira Shimoda
Kenichiro Akao
Naoto Koyama
Kenichiro Akao
Naoto Koyama