Title:
ゴーシェ病を治療するための、グルコイミダゾール誘導体およびポリヒドロキシシクロヘキセニルアミン誘導体
Document Type and Number:
Japanese Patent JP2007510753
Kind Code:
A
Abstract:
The present invention provides novel hydroxy piperidine (HP) derivatives having (i) a positive charge at the position corresponding to the anomeric position of a pyranose ring; (ii) a short, flexible linker emanating from the corresponding position of the ring oxygen in a pyranose; and (iii) a lipophilic moiety connected to the linker and pharmaceutically acceptable salts thereof. The linker can be absent if the lipophilic moiety corresponds to a hydrocarbon chain with a linear length of 6 or more carbons. The present invention further provides a method for treating individuals having Gaucher disease by administering the novel HP derivative as “active-site specific chaperones” for the mutant glucocerebrosidase associated with the disease.
Inventors:
Fan, jean-can
Zoo, xiaoshan
Chess, kamlesh
Zoo, xiaoshan
Chess, kamlesh
Application Number:
JP2006539869A
Publication Date:
April 26, 2007
Filing Date:
November 12, 2004
Export Citation:
Assignee:
Amicus Therapeutics, Inc.
International Classes:
C07D471/04; A61K31/437; A61K31/445; A61K31/454; A61K31/4745; A61K31/50; A61K31/501; A61K31/7088; A61K38/46; A61K48/00; A61P1/16; A61P7/06; A61P19/00; A61P25/00; A61P43/00; C07D211/40; C07D471/02; C12N9/96; C12N9/99; A61K31/13; A61K
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Masakazu Noda