Title:
シクロペンチル誘導体
Document Type and Number:
Japanese Patent JP2007512272
Kind Code:
A
Abstract:
This invention is related to novel cyclopentyl derivatives of the following general formula (I) wherein X is methylene, oxygen, sulphur or a NR<7> group; R<1> is a straight or branched C1-C8 alkyl or C3-C8 alkenylene or C3-C8 alkynylene chain, optionally substituted with CF3, phenyl, phenoxy or naphthyl, the aromatic rings optionally substituted by one or more C1-C4 alkyl, halogens, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R<2>, R<3> are independently hydrogen, a C1-C3 alkyl chain,halogen, trifluoromethyl, hydroxy or C1-C4 alkoxy groups; R<4>, R<5>, R<6>, R<7> are independently hydrogen or C1-C6 alkyl; and the pharmaceutically acceptable salts thereof that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
Inventors:
Meloni, clown
Sube David, Sibere Maria
Restivo, Alessandra
Forani, Roberto
Salvati, Patricia
Sube David, Sibere Maria
Restivo, Alessandra
Forani, Roberto
Salvati, Patricia
Application Number:
JP2006540265A
Publication Date:
May 17, 2007
Filing Date:
November 12, 2004
Export Citation:
Assignee:
NEWRON PHARMACEUTICALS S.P.A.
International Classes:
C07C237/24; A61K31/16; A61K31/164; A61P1/00; A61P3/00; A61P9/00; A61P13/00; A61P25/00; A61P25/18; A61P27/02; A61P29/00; A61P43/00; C07C231/12
Domestic Patent References:
| JP2003511416A | 2003-03-25 | |||
| JPH11506787A | 1999-06-15 | |||
| JPH10330380A | 1998-12-15 |
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda