Title:
併用療法
Document Type and Number:
Japanese Patent JP2007512303
Kind Code:
A
Abstract:
The invention provides combination therapies and methods for the treatment of cancers associates with p53 mutations. The method comprises the separate, sequential or simultaneous administration of a therapeutically effective amount of a) a specific binding member, for example CH-11, which binds to a cell death receptor, for example Fas, or a nucleic acid encoding said binding member and b) a chemotherapeutic agent, wherein the chemotherapeutic agent is a topoisomerase inhibitor, for example CPT-1 or a thymidylate synthase inhibitor, for example TDX. Synergistic cytotoxic effects have been demonstrated using such combinations.
Inventors:
Johnston, Patrick, Gerald
Longley, Daniel
Longley, Daniel
Application Number:
JP2006540620A
Publication Date:
May 17, 2007
Filing Date:
November 26, 2004
Export Citation:
Assignee:
Fujong Anti Bodies Limited
International Classes:
A61K31/7052; A61K31/4545; A61K31/517; A61K31/7088; A61K39/395; A61K45/00; A61K45/06; A61P35/00
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Masakazu Noda