Title:
7-エチル-10-ヒドロキシカンプトテシンの製造方法
Document Type and Number:
Japanese Patent JP2007517778
Kind Code:
A
Abstract:
The method of manufacturing of 7-ethyl-10-hydroxycamptothecin of formula I characterized in that 7-ethyl-1,2,6,7-tetrahydrocampotothecin of formula IV is oxidized with an oxidizing agent selected from the group comprising iodosobenzene, an ester of iodosobenzene, sodium periodate, potassium periodate, potassium peroxodisulfate and ammonium peroxodisulfate, in a solvent formed by a saturated aliphatic monocarboxylic add containing 1 to 3 carbon atoms, and in the presence of water.
Inventors:
Dubrovolny, Petr
Application Number:
JP2006544199A
Publication Date:
July 05, 2007
Filing Date:
December 14, 2004
Export Citation:
Assignee:
Privat-Rakema, A.S.
International Classes:
C07D491/22
Domestic Patent References:
| JPS595188A | 1984-01-12 |
Foreign References:
| WO2003068778A1 | 2003-08-21 | |||
| US4473692A | 1984-09-25 |
Attorney, Agent or Firm:
Masao Okabe
Nobuaki Kato
Okabe
Shinichi Usui
Ikuo Fujino
Takao Ochi
Teruhisa Motomiya
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura
Nobuaki Kato
Okabe
Shinichi Usui
Ikuo Fujino
Takao Ochi
Teruhisa Motomiya
Norimichi Takanashi
Tsuneo Kobayashi
Masami Saito
Katsuhiko Kimura