Title:
プロセス中及び完成セボフルランの両方の分析のクロマトグラフ法
Document Type and Number:
Japanese Patent JP2007518078
Kind Code:
A
Abstract:
A method in which organic matter found in a crude sevoflurane may be separated, identified, and quantified using a CARBOWAX(TM) (polyethylene glycol) capillary gas chromatographic column or an alkyl polysiloxane capillary gas chromatographic column. Also provided is a process control method for the production of sevoflurane, wherein the content of a particular component in one of the following steps is determined, and in that, assuming this as a variable, the treatment condition of the step is adjusted: 1) a step of extracting, or cooling to form two layers, and/or distilling a mixture of crude sevoflurane and hydrogen fluoride (HF) in order to isolate the majority of the sevoflurane and 2) an optional step of purifying the crude sevoflurane and 3) a step of distilling crude sevoflurane. Also provided is a method for determining the impurity level of a purified sevoflurane that is acceptable for use in human/animal anesthesia.
Inventors:
Barry, Jones
Crimian, Ashot
Swinson, Joel
Cross, pole
Crimian, Ashot
Swinson, Joel
Cross, pole
Application Number:
JP2006547609A
Publication Date:
July 05, 2007
Filing Date:
January 04, 2005
Export Citation:
Assignee:
Halo Carbon Products Corporation
International Classes:
G01N30/88; B01J20/285; C07C41/01; C07C41/16; C07C41/42; C07C43/12; G01N30/06; G01N30/60; G01N30/86; G01N30/02
Domestic Patent References:
| JPH11116521A | 1999-04-27 | |||
| JPH07280790A | 1995-10-27 | |||
| JP2003530323A | 2003-10-14 |
Attorney, Agent or Firm:
Shinji Miura