面に対して両親媒性のポリアリール及びポリアリールアルキニルのポリマー及びオリゴマー並びにそれらの使用 - The Trustees of the University of Pennsylvania

Title:

面に対して両親媒性のポリアリール及びポリアリールアルキニルのポリマー及びオリゴマー並びにそれらの使用

Document Type and Number:

Japanese Patent JP2007523064

Kind Code:

A

Abstract:

The present invention discloses facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers of formula (Ia), compositions thereof, preparation thereof and their use as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy R 1 -A 1 -s-A 2 -s-A 1 -R 2 Formula (Ia) wherein A 1 and A 2 are independently substituted or unsubstituted arylene or heteroarylene, s is absent, or -CH=CH- or C¡C- and R 1 and R 2 are as defined in claim 1. Examples of compounds of formula (Ia) are the following

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Inventors:

Degrad, William F
Riu, Darui
Tew, Gregory N
Klein, Michael Elle

Application Number:

JP2006551286A

Publication Date:

August 16, 2007

Filing Date:

January 21, 2005

Export Citation:

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Assignee:

The Trustees of the University of Pennsylvania
Degrad, William F
Riu, Darui
Tew, Gregory N
Klein, Michael Elle

International Classes:

A61K31/137; A61K31/14; A61K31/155; A61K31/166; A61K31/74; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P39/02; C07C211/27; C07C211/29; C07C217/42; C07C217/58; C07C233/66; C07C233/78; C07C279/06; C07C279/08; C07C279/12

Domestic Patent References:

JPS56123903A	1981-09-29
JPH072808A	1995-01-06
JPS63500943A	1988-04-07
JPH10505592A	1998-06-02
JPS56123903A	1981-09-29
JPH072808A	1995-01-06
JPS63500943A	1988-04-07
JPH10505592A	1998-06-02

Foreign References:

WO2002095044A2	2002-11-28
US5073564A	1991-12-17
US4826829A	1989-05-02
WO2001055085A1	2001-08-02
WO2002095044A2	2002-11-28
US5073564A	1991-12-17
US4826829A	1989-05-02
WO2001055085A1	2001-08-02
WO2002072007A2	2002-09-19

Other References:

JPN6011022509; ＳＨＯＲＴＥＬＬ，Ｄ．Ｂ．　ｅｔ　ａｌ．: 'Ｓｏｌｉｄ-ｐｈａｓｅ　ａｐｐｒｏａｃｈｅｓ　ｔｏｗａｒｄ　ｃｙｃｌｉｃ　ｏｌｉｇｏｍｅｒｓ' ＴｅｔｒａｈｅｄｒｏｎＶｏｌ．５７, 2001, ｐ．９０５５-６５
JPN6011022512; ＴＥＷ，Ｇ．Ｎ．: 'Ａｍｐｈｉｐｈｉｌｉｃ　ｐｈｅｎｙｌｅｎｅ　ｅｔｈｙｎｙｌｅｎｅｓ' Ｐｏｌｙｍｅｒ　ｐｒｅｐｒｉｎｔｓＶｏｌ．４４，　Ｎｏ．２, 2003, ｐ．４５２
JPN6011022520; ＨＡＵＧＷＩＴＺ，Ｒ．Ｄ．　ｅｔ　ａｌ: 'Ａｎｔｉｐａｒａｓｉｔｉｃ　ａｇｅｎｔｓ．　　６．　　Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ａｎｔｈｅｌｍｉｎｔｉｃ　ａｃｔｉｖｉｔｉｅｓ　ｏｆ　ｎｏｖｅｌ　ｉｓｏｔｈｉｏｃｙａｎａｔｏｐｈｅｎｙｌ-１，２，４' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２８，　Ｎｏ．９, 1985, ｐ．１２３４-４１
JPN6011022523; ＭＡＲＫＯＶＡＣ，Ａ．　ｅｔ　ａｌ．: 'Ａｎｔｉｍａｌａｒｉａｌｓ．　　１２．　　Ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　ｃａｒｂｏｎ　ｉｓｏｓｔｅｒｅｓ　ｏｆ　ｓｅｌｅｃｔｅｄ　４-ｐｙｒｉｄｉｎｅｍｅｔｈａｎｏｌｓ　ａｓ　ｓｕｐｐｒｅｓｓｉｖｅ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２３，　Ｎｏ．１１, 1980, ｐ．１１９８-２０１
JPN6011022516; ＣＨＡＰＭＡＮ，Ｒ．Ｌ．　ｅｔ　ａｌ: 'Ｓｍａｌｌ　ｍｏｌｅｃｕｌｅ　ｍｏｄｕｌａｔｏｒｓ　ｏｆ　ＨＩＶ　Ｒｅｖ／Ｒｅｖ　ｒｅｓｐｏｎｓｅ　ｅｌｅｍｅｎｔ　ｉｎｔｅｒａｃｔｉｏｎ　ｉｄｅｎｔｉｆｉｅｄ　ｂｙ　ｒａｎｄｏｍ　ｓｃｒｅｅｎｉｎｇ' Ａｎｔｉｖｉｒａｌ　ＲｅｓｅａｒｃｈＶｏｌ．５４，　Ｎｏ．３, 2002, ｐ．１４９-６２
JPN6011022509; ＳＨＯＲＴＥＬＬ，Ｄ．Ｂ．　ｅｔ　ａｌ．: 'Ｓｏｌｉｄ-ｐｈａｓｅ　ａｐｐｒｏａｃｈｅｓ　ｔｏｗａｒｄ　ｃｙｃｌｉｃ　ｏｌｉｇｏｍｅｒｓ' ＴｅｔｒａｈｅｄｒｏｎＶｏｌ．５７, 2001, ｐ．９０５５-６５
JPN6011022512; ＴＥＷ，Ｇ．Ｎ．: 'Ａｍｐｈｉｐｈｉｌｉｃ　ｐｈｅｎｙｌｅｎｅ　ｅｔｈｙｎｙｌｅｎｅｓ' Ｐｏｌｙｍｅｒ　ｐｒｅｐｒｉｎｔｓＶｏｌ．４４，　Ｎｏ．２, 2003, ｐ．４５２
JPN6011022520; ＨＡＵＧＷＩＴＺ，Ｒ．Ｄ．　ｅｔ　ａｌ: 'Ａｎｔｉｐａｒａｓｉｔｉｃ　ａｇｅｎｔｓ．　　６．　　Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ａｎｔｈｅｌｍｉｎｔｉｃ　ａｃｔｉｖｉｔｉｅｓ　ｏｆ　ｎｏｖｅｌ　ｉｓｏｔｈｉｏｃｙａｎａｔｏｐｈｅｎｙｌ-１，２，４' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２８，　Ｎｏ．９, 1985, ｐ．１２３４-４１
JPN6011022523; ＭＡＲＫＯＶＡＣ，Ａ．　ｅｔ　ａｌ．: 'Ａｎｔｉｍａｌａｒｉａｌｓ．　　１２．　　Ｐｒｅｐａｒａｔｉｏｎ　ｏｆ　ｃａｒｂｏｎ　ｉｓｏｓｔｅｒｅｓ　ｏｆ　ｓｅｌｅｃｔｅｄ　４-ｐｙｒｉｄｉｎｅｍｅｔｈａｎｏｌｓ　ａｓ　ｓｕｐｐｒｅｓｓｉｖｅ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２３，　Ｎｏ．１１, 1980, ｐ．１１９８-２０１
JPN6011022516; ＣＨＡＰＭＡＮ，Ｒ．Ｌ．　ｅｔ　ａｌ: 'Ｓｍａｌｌ　ｍｏｌｅｃｕｌｅ　ｍｏｄｕｌａｔｏｒｓ　ｏｆ　ＨＩＶ　Ｒｅｖ／Ｒｅｖ　ｒｅｓｐｏｎｓｅ　ｅｌｅｍｅｎｔ　ｉｎｔｅｒａｃｔｉｏｎ　ｉｄｅｎｔｉｆｉｅｄ　ｂｙ　ｒａｎｄｏｍ　ｓｃｒｅｅｎｉｎｇ' Ａｎｔｉｖｉｒａｌ　ＲｅｓｅａｒｃｈＶｏｌ．５４，　Ｎｏ．３, 2002, ｐ．１４９-６２

Attorney, Agent or Firm:

Heikichi Odashima

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