Title:
7-(4-ブロモブトキシ)-3,4-ジヒドロカルボスチリルを生成する方法
Document Type and Number:
Japanese Patent JP2007523068
Kind Code:
A
Abstract:
The invention encompasses synthesizing 7-(4-bromobutoxy)-3,4-dihydrocarbostyril by mixing 7-hydroxy-tetrahydroquinolinone, dibromobutane, and at least one base to form a reaction mixture; heating the reaction mixture; cooling the reaction mixture; and isolating the 7-(4-bromobutoxy)-3,4-dihydrocarbostyril from the reaction mixture. The invention also encompasses using phase transfer catalysts during the reaction.
Inventors:
Dorritsky, Ben-Sion
Hildesheim, Jean
Berlin, Alisa
Hildesheim, Jean
Berlin, Alisa
Application Number:
JP2006551643A
Publication Date:
August 16, 2007
Filing Date:
February 07, 2005
Export Citation:
Assignee:
Teva Pharmaceutical Industries Limited
International Classes:
C07D215/22; A61K31/4706; C07D215/227; A61K31/497; A61P25/18; C07B61/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Shintaro Koike
Takashi Ishida
Fukumoto product
Tetsuji Koga
Shintaro Koike