Title:
エスシタロプラムの製造に使用できる中間体の分離方法
Document Type and Number:
Japanese Patent JP2007524678
Kind Code:
A
Abstract:
The invention relates to a method of separating and isolating an acylated derivative of 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxybutyl]-3-hydroxymethylbenzonitrile by reaction of a mixture of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile and an acylated derivative thereof with a compound which form a derivative of the 4-[(S)-4-dimethylamino-1-(4-fluorophenyl)-1-hydroxy-butyl]-3-hydroxymethylbenzonitrile containing a carboxylic acid group. The acylated derivative containing a carboxylic acid group precipitates once it is formed and may easily be separated from the reaction mixture.
Inventors:
Ringsee Rals Ole
Application Number:
JP2006552461A
Publication Date:
August 30, 2007
Filing Date:
February 02, 2005
Export Citation:
Assignee:
Her Lundbeck Actiezer Scabet
International Classes:
C07C253/34; C07B57/00; C07C253/30; C07C255/53; C07C255/59; C07D307/87; C12P17/04; C12P41/00
Domestic Patent References:
| JPH0236177A | 1990-02-06 | |||
| JPS6187654A | 1986-05-06 | |||
| JP2004538276A | 2004-12-24 | |||
| JP2004536093A | 2004-12-02 | |||
| JP2005513069A | 2005-05-12 | |||
| JP2005518445A | 2005-06-23 | |||
| JP2005522419A | 2005-07-28 | |||
| JP2005525993A | 2005-09-02 | |||
| JP2005535322A | 2005-11-24 | |||
| JP2006511559A | 2006-04-06 |
Attorney, Agent or Firm:
Mitsufumi Esaki
Okumura Yoshimichi
Blacksmith
Okumura Yoshimichi
Blacksmith