Title:
代謝調節型グルタミン酸受容体-5の調節物質としてのビピリジルアミド
Document Type and Number:
Japanese Patent JP2007524682
Kind Code:
A
Abstract:
The present invention is directed to novel amides such as those of Formula (I): (I) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel amides and/or compositions containing these compounds.
Inventors:
Bonneuf, Celine
Kamenetka, Theodore M
Bernier, Jean-Mitzier
Kamenetka, Theodore M
Bernier, Jean-Mitzier
Application Number:
JP2006553189A
Publication Date:
August 30, 2007
Filing Date:
February 09, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D213/81; A61K31/44; A61K31/444; A61K31/4709; A61K31/4965; A61K31/497; A61K31/498; A61K31/695; A61P25/02; A61P25/04; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P29/00; A61P43/00; C07D213/84; C07D241/28; C07D401/00; C07D401/12; C07D401/14; C07D403/00; C07D405/00; C07D405/14; C07D409/00; C07D409/14; C07D411/00; C07D413/00; C07D417/00; C07D419/00; C07F7/12; A61P3/04
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura