Title:
組み換え細胞毒性RNAseを含む融合タンパク質
Document Type and Number:
Japanese Patent JP2007524686
Kind Code:
A
Abstract:
Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may be used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.
Inventors:
Goldenberg, David M
Hansen Jay, Hansen
Chang, Chiang-Shin
Vanama, Sai Raja
Rossi, Edmund A.
Hansen Jay, Hansen
Chang, Chiang-Shin
Vanama, Sai Raja
Rossi, Edmund A.
Application Number:
JP2006553352A
Publication Date:
August 30, 2007
Filing Date:
February 14, 2005
Export Citation:
Assignee:
Immunomedics, Inc.
International Classes:
C07K16/46; A61K38/16; A61K39/395; A61K47/48; A61K51/08; A61K51/10; A61P1/04; A61P1/16; A61P3/10; A61P5/14; A61P7/02; A61P7/04; A61P7/06; A61P9/14; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P21/00; A61P21/02; A61P21/04; A61P25/00; A61P25/04; A61P29/00; A61P31/04; A61P31/06; A61P31/08; A61P31/10; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P33/00; A61P33/02; A61P33/06; A61P33/10; A61P33/12; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07K19/00; C12N9/22; C12N15/09; C12P21/00; C12P21/08
Domestic Patent References:
| JP2001507944A | 2001-06-19 | |||
| JP2002512774A | 2002-05-08 |
Foreign References:
| WO2004013180A2 | 2004-02-12 |
Other References:
JPN6010061036; Ｍｏｌｅｃｕｌａｒ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．３０， Ｎｏ．１, 1993, ｐ．１０５-１０８
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo