Title:
4-アミノ-7,8-ジヒドロプテリジン類、これらを含む医薬組成物、および一酸化窒素レベル上昇によってもたらされる疾病の治療に対するそれらの使用
Document Type and Number:
Japanese Patent JP2007525407
Kind Code:
A
Abstract:
The present invention relates to the area of NO synthase inhibition and, more particularly, relates to novel 4-amino-7,8-dihydropteridines, pharmaceutical compositions containing said compounds, and the use of said compounds in the treatment of a disorder characterized by a disturbed nitric oxide level.
Inventors:
Dobble Hofer, Robert
Tegutomire, Frank
Tegutomire, Frank
Application Number:
JP2005512684A
Publication Date:
September 06, 2007
Filing Date:
December 30, 2003
Export Citation:
Assignee:
Vasofarm Biotech Game Behr
International Classes:
C07D475/08; A61K31/519; A61P1/02; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P13/12; A61P19/02; A61P21/00; A61P25/00; A61P25/06; A61P25/08; A61P25/28; A61P29/00; A61P31/04; A61P31/12; A61P35/00; A61P37/06
Domestic Patent References:
| JPS63502892A | 1988-10-27 |
Foreign References:
| EP0906913A1 | 1999-04-07 | |||
| WO1995032203A2 | 1995-11-30 |
Other References:
JPN6010033662, Ｍｉｃｈａｅｌ Ｃｈａｙｋｏｖｓｋｙ, "Ｄｉｒｅｃｔ Ｎ８−Ａｌｋｙｌａｔｉｏｎ ｏｆ ２，４−Ｄｉａｍｉｎｏ−７，８−ｄｉｈｙｄｒｏｐｔｅｒｉｄｉｎｅｓ． Ｐｒｅｐａｒａｔｉｏｎ ｏｆ ７，８−Ｄｉｈｙｄｒｏ−８−ｍｅｔｈｙｌｍｅｔｈｏｔ", Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ, 1975, Ｖｏｌ．４０， Ｎｏ．１, ｐ．１４５−１４６
JPN6010033664, Ｍｏｒｒｉｓ Ｚｉｍｍｅｒｍａｎ ｅｔ ａｌ．, "Ｉｎｈｉｂｉｔｏｒｓ ｏｆ Ｆｏｌａｔｅ Ｂｉｏｓｙｎｔｈｅｓｉｓ． １． Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｄｉｈｙｄｒｏｎｅｏｐｔｅｒｉｎ Ａｌｄｏｌａｓｅ ｂｙ Ｐｔｅｒｉｄｉｎｅ Ｄｅｒｉｖａｔｉｖ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1977, Ｖｏｌ．２０， Ｎｏ．９, ｐ．１２１３−１２１５
JPN6010033667, Ｃａｒｒｏｌｌ Ｔｅｍｐｌｅ， Ｊｒ． ｅｔ ａｌ．, "１，２−Ｄｉｈｙｄｒｏｐｙｒｉｄｏ［３，４−ｂ］ｐｙｒａｚｉｎｅｓ： Ｓｔｒｕｃｔｕｒｅ−Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐｓ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1983, Ｖｏｌ．２６， Ｎｏ．１, ｐ．９１−９５
JPN6010033670, Ｍ． Ｇ． Ｎａｉｒ, "Ｆｏｌａｔｅ Ａｎａｌｏｇｕｅｓ． ２４． Ｓｙｎｔｈｅｓｅｓ ｏｆ ｔｈｅ Ａｎｔｉｔｕｍｏｒ Ａｇｅｎｔｓ １０−Ｄｅａｚａａｍｉｎｏｐｔｅｒｉｎ （１０−ＤＡＡＭ） ａｎｄ １０−Ｅｔｈｙｌ−１", Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ, 1985, Ｖｏｌ．５０， Ｎｏ．１１, ｐ．１８７９−１８８４
JPN6010033671, Ｒａｌｐｈ Ｂａｕｒ ｅｔ ａｌ．, "６０． Ｐｔｅｒｉｄｉｎｅｓ． Ｃｈｅｍｉｃａｌ Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｄｅｏｘｙｓｅｐｉａｐｔｅｒｉｎ ａｎｄ ６−Ａｃｙｌｐｔｅｒｉｄｉｎｅｓ ｂｙ Ａｃｙｌ Ｒａｄｉｃａｌ Ｓｕｂｓｔｉｔｕ", Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ, 1988, Ｖｏｌ．７１， Ｎｏ．３, ｐ．５３１−５４３
JPN6010033664, Ｍｏｒｒｉｓ Ｚｉｍｍｅｒｍａｎ ｅｔ ａｌ．, "Ｉｎｈｉｂｉｔｏｒｓ ｏｆ Ｆｏｌａｔｅ Ｂｉｏｓｙｎｔｈｅｓｉｓ． １． Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｄｉｈｙｄｒｏｎｅｏｐｔｅｒｉｎ Ａｌｄｏｌａｓｅ ｂｙ Ｐｔｅｒｉｄｉｎｅ Ｄｅｒｉｖａｔｉｖ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1977, Ｖｏｌ．２０， Ｎｏ．９, ｐ．１２１３−１２１５
JPN6010033667, Ｃａｒｒｏｌｌ Ｔｅｍｐｌｅ， Ｊｒ． ｅｔ ａｌ．, "１，２−Ｄｉｈｙｄｒｏｐｙｒｉｄｏ［３，４−ｂ］ｐｙｒａｚｉｎｅｓ： Ｓｔｒｕｃｔｕｒｅ−Ａｃｔｉｖｉｔｙ Ｒｅｌａｔｉｏｎｓｈｉｐｓ", Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1983, Ｖｏｌ．２６， Ｎｏ．１, ｐ．９１−９５
JPN6010033670, Ｍ． Ｇ． Ｎａｉｒ, "Ｆｏｌａｔｅ Ａｎａｌｏｇｕｅｓ． ２４． Ｓｙｎｔｈｅｓｅｓ ｏｆ ｔｈｅ Ａｎｔｉｔｕｍｏｒ Ａｇｅｎｔｓ １０−Ｄｅａｚａａｍｉｎｏｐｔｅｒｉｎ （１０−ＤＡＡＭ） ａｎｄ １０−Ｅｔｈｙｌ−１", Ｊｏｕｒｎａｌ ｏｆ Ｏｒｇａｎｉｃ Ｃｈｅｍｉｓｔｒｙ, 1985, Ｖｏｌ．５０， Ｎｏ．１１, ｐ．１８７９−１８８４
JPN6010033671, Ｒａｌｐｈ Ｂａｕｒ ｅｔ ａｌ．, "６０． Ｐｔｅｒｉｄｉｎｅｓ． Ｃｈｅｍｉｃａｌ Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｄｅｏｘｙｓｅｐｉａｐｔｅｒｉｎ ａｎｄ ６−Ａｃｙｌｐｔｅｒｉｄｉｎｅｓ ｂｙ Ａｃｙｌ Ｒａｄｉｃａｌ Ｓｕｂｓｔｉｔｕ", Ｈｅｌｖｅｔｉｃａ Ｃｈｉｍｉｃａ Ａｃｔａ, 1988, Ｖｏｌ．７１， Ｎｏ．３, ｐ．５３１−５４３
Attorney, Agent or Firm:
Hidekazu Miyoshi
Masakazu Ito
Yuko Hara
Masakazu Ito
Yuko Hara