Title:
REおよびTCトリカルボニル錯体のための配位子を含有する二官能性三座ピラゾリル
Document Type and Number:
Japanese Patent JP2007525452
Kind Code:
A
Abstract:
The present invention relates to a chelating agent of the general formula: (I), wherein m is 0 or 1; X is NR4 or S; Y is SR5, NHR5 or P(R5)2; R1 and R3 are the same or different and are selected from H, alkyl or aryl; R2 is H, COOH, NHR6 or (CH2)nCOOR6; R4 is H, alkyl, aryl, (CH2)nCOOR6 or (CH2)nOR6; R5 is H, alkyl, aryl, (CH2)nCOOR6 or (CH2)nOR6, R6 is H, alkyl or aryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; and when R1=R3=CH3, R2, R4 and R5 are not all three H. The invention further relates to a method and kit for the preparation of radiolabeled biomolecules while using the chelating agent.
Inventors:
Isabelle Ehi Santos
Joan de Galamba Coheia
Antonio Emi Hocha Paulo
Suzana Alves
Fute Bittle
Joan de Galamba Coheia
Antonio Emi Hocha Paulo
Suzana Alves
Fute Bittle
Application Number:
JP2006510091A
Publication Date:
September 06, 2007
Filing Date:
April 15, 2004
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
A61K51/00; A61K49/00; A61K51/04; A61K51/08; A61K51/10; A61P35/00; C07D231/12; C07D231/14
Domestic Patent References:
| JP2001516360A | 2001-09-25 |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Mitsutaka Iwasaki
Shoji Nakajima