Title:
ペプチド結合サロゲートを組み入れた空間的に規定された大環状分子
Document Type and Number:
Japanese Patent JP2007526895
Kind Code:
A
Abstract:
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
Inventors:
Deronchamp, Pierre
Dolly, eve
Uere, Backpack
Villeneuve, Gerard
Lamasshan, Mahesh
Fortin, Daniel
Peterson, Mark
Hoveida, Hamid
Beauville, Sylvie
Marceau, Erik
Dolly, eve
Uere, Backpack
Villeneuve, Gerard
Lamasshan, Mahesh
Fortin, Daniel
Peterson, Mark
Hoveida, Hamid
Beauville, Sylvie
Marceau, Erik
Application Number:
JP2006521361A
Publication Date:
September 20, 2007
Filing Date:
August 02, 2004
Export Citation:
Assignee:
Transzyme Pharma
International Classes:
C07K5/08; A61K38/00; A61K38/12; A61P1/00; A61P1/14; A61P3/00; A61P5/10; A61P43/00; C07D491/02; C07K1/04; C07K5/00; C07K5/10
Domestic Patent References:
| JP2007527863A | 2007-10-04 |
Foreign References:
| WO2002016404A1 | 2002-02-28 |
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Arihara Koichi
Matsushima Tetsuo