Title:
複合生物学的分子及びそれらの調製
Document Type and Number:
Japanese Patent JP2007527382
Kind Code:
A
Abstract:
A process for the preparation of a compound of the general formula:
in which one of X and X' represents polyethylene glycol, and the other represents a hydrogen atom;
each Q independently represents a linking group;
W represents a keto group CO, an ester group -O-CO- or a sulphone group -SO 2 -, or a group obtained by reduction of such a group; or, if X' represents polyethylene glycol, X-Q-W-together represent a cyano group;
Z represents a protein which is linked to A and B via two thiol groups which have been derived from a disulphide bridge in the protein; A is a C 1-5 alkylene or alkenylene chain; and
B is a bond or a C 1-4 alkylene or alkenylene chain; which comprises reducing a disulfide bridge in a protein, and reacting the resultant product in an aqueous reaction medium with either (i) a compound of the general formula
in which X, X', Q, A, B and L have the meanings given above, W' represents a keto or aldehyde group CO, an ester group
-O-CO- or a sulphone group -SO 2 -, and each L independently represents a leaving group;
or (ii) a compound of the general formula
in which X, X', Q, W', A and L have the meanings given for the general formula II, and m represents an integer 1 to 4. Also claimed is novel intermediate ±-methoxy-É-4-[2,2-bis[(p-tolylsulfonyl)methyl]-acetyl]benzamide poly(ethylene glycol).
Inventors:
Godwin Antony Robert
Pedon elisa
Choi-won
Shaunak Sunil
Brocchini stephen james
Pedon elisa
Choi-won
Shaunak Sunil
Brocchini stephen james
Application Number:
JP2006518372A
Publication Date:
September 27, 2007
Filing Date:
July 12, 2004
Export Citation:
Assignee:
Polycerix Limited
International Classes:
A61K47/48; A61K31/77; A61K38/21; A61K38/43; A61K39/395; A61P37/02; C07K14/56; C07K16/00; C12N9/10; C12N9/82; C12N15/09
Domestic Patent References:
| JP2002512983A | 2002-05-08 | |||
| JP2002506087A | 2002-02-26 |
Foreign References:
| WO1995025764A1 | 1995-09-28 |
Attorney, Agent or Firm:
Eiji Saegusa
Kakehi Yuro
Kenji Saito
Kakehi Yuro
Kenji Saito