Title:
薬剤溶出式の植設可能な医療デバイスによる前駆内皮細胞の捕捉方法
Document Type and Number:
Japanese Patent JP2007528275
Kind Code:
A
Abstract:
A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent (100) and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances (110) for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand (120) such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug- coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
Inventors:
Cotton, Robert John Jr.
Rowland, Stephen M
Davis, Horace Earl
Ctrick, Mitchell Jay Bee
Rowland, Stephen M
Davis, Horace Earl
Ctrick, Mitchell Jay Bee
Application Number:
JP2007502937A
Publication Date:
October 11, 2007
Filing Date:
March 10, 2005
Export Citation:
Assignee:
Obersnake Medical Incorporated
International Classes:
A61L31/00; A61F2/00; A61F2/852; A61F2/86
Domestic Patent References:
| JP2003526477A | 2003-09-09 |
Foreign References:
| WO2003065881A2 | 2003-08-14 | |||
| WO2003099169A1 | 2003-12-04 |
Attorney, Agent or Firm:
Warren G. Simor