Title:
IGF-1R阻害剤としてのテトラヒドロイソキノリンおよびテトラヒドロベンゾアゼピン誘導体
Document Type and Number:
Japanese Patent JP2007528877
Kind Code:
A
Abstract:
Compounds of the formula (I): where R2, R5, R6 have the meanings as given in the description, and U, V and W, respectively, may be CR2′, CR4′ and CR6′, respectively (with the definitions of R2′, R4′ and R6′ again as in the description), or may be N, were synthesized. They were found to down-regulate or inhibit the expression or function of the IGF-1 receptor.
Inventors:
Jan Gunzinger
Kurtruder
Kurtruder
Application Number:
JP2007502162A
Publication Date:
October 18, 2007
Filing Date:
March 12, 2004
Export Citation:
Assignee:
ANALYTECON S.A.
International Classes:
C07D217/14; A61K31/4709; A61K31/472; A61K31/4725; A61K31/55; A61K45/00; A61P9/10; A61P17/06; A61P19/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07D217/16; C07D223/04; C07D233/16; C07D401/04; C07D401/12; C12Q1/02
Domestic Patent References:
| JP2001294575A | 2001-10-23 | |||
| JPS477381A | ||||
| JPS62283960A | 1987-12-09 | |||
| JPS477381B1 |
Foreign References:
| WO2002046164A1 | 2002-06-13 | |||
| US6337338B1 | 2002-01-08 | |||
| WO2003048133A1 | 2003-06-12 | |||
| WO1990002119A1 | 1990-03-08 |
Other References:
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 24(7), JPN6010015261, 2003, pages 1041 - 1044, ISSN: 0001576450
Attorney, Agent or Firm:
Mitsue Obuchi
Yukio Fuse
Tatsuya Ina
Yukio Fuse
Tatsuya Ina