Title:
セルトリ細胞および筋様細胞を含有する組成物、並びに細胞性移植における該組成物の使用
Document Type and Number:
Japanese Patent JP2007530416
Kind Code:
A
Abstract:
The present invention relates to the use of Sertoli cells and myoid cells for creating an immunologically privileged site in a mammalian subject, thereby facilitating the transplantation of cells that produce a biological factor in the treatment of a disease that results from a deficiency of such biological factor. Pharmaceutical compositions containing Sertoli cells and myoid cells, as well as therapeutic methods relating to the use of these cells are provided by the present invention.
Inventors:
Janet Dufour
Craig Halberstat
Richel Hemendinger
Ray Buoy Lajotte
Alfred B. Bass Conceros
Paul Goas
Dwayne Emerych
Greg Cobat
Craig Halberstat
Richel Hemendinger
Ray Buoy Lajotte
Alfred B. Bass Conceros
Paul Goas
Dwayne Emerych
Greg Cobat
Application Number:
JP2006518816A
Publication Date:
November 01, 2007
Filing Date:
July 02, 2004
Export Citation:
Assignee:
Janet Dufour
Craig Halberstat
Richel Hemendinger
Ray Buoy Lajotte
Alfred B. Bass Conceros
Paul Goas
Dwayne Emerych
Greg Cobat
Craig Halberstat
Richel Hemendinger
Ray Buoy Lajotte
Alfred B. Bass Conceros
Paul Goas
Dwayne Emerych
Greg Cobat
International Classes:
A61K35/12; A61K35/34; A61K35/39; A61K35/48; A61K45/00; A61L27/00; A61P5/48; A61P37/06; C12N5/071; C12N15/09; A61K
Other References:
JPN5007024250, ＤＵＦＯＵＲ, ＪＯＵＲＮＡＬ ＯＦ ＡＮＤＲＯＬＯＧＹ, 200209, Ｖ２３ Ｎ５, Ｐ６３５−６４４
JPN7010002977, ＫＯＲＢＵＴＴ，Ｇ．Ｓ． ｅｔ ａｌ, "Ｃｏｔｒａｎｓｐｌａｎｔａｔｉｏｎ ｏｆ ａｌｌｏｇｅｎｅｉｃ ｉｓｌｅｔｓ ｗｉｔｈ ａｌｌｏｇｅｎｅｉｃ ｔｅｓｔｉｃｕｌａｒ ｃｅｌｌ ａｇｇｒｅｇａｔｅｓ ａｌｌｏｗｓ ｌｏｎｇ−ｔｅｒｍ ｇ", Ｄｉａｂｅｔｅｓ, 1997, Ｖｏｌ．４６， Ｎｏ．２, ｐ．３１７−２２
JPN7010002978, ＷＩＬＬＩＮＧ，Ａ．Ｅ． ｅｔ ａｌ, "Ｓｅｒｔｏｌｉ ｃｅｌｌｓ ｄｅｃｒｅａｓｅ ｍｉｃｒｏｇｌｉａｌ ｒｅｓｐｏｎｓｅ ａｎｄ ｉｎｃｒｅａｓｅ ｅｎｇｒａｆｔｍｅｎｔ ｏｆ ｈｕｍａｎ ｈＮＴ ｎｅｕｒｏｎｓ ｉｎ ｔｈｅ ｈｅｍｉ", Ｂｒａｉｎ Ｒｅｓ Ｂｕｌｌ, 1999, Ｖｏｌ．４８， Ｎｏ．４, ｐ．４４１−４
JPN7010002977, ＫＯＲＢＵＴＴ，Ｇ．Ｓ． ｅｔ ａｌ, "Ｃｏｔｒａｎｓｐｌａｎｔａｔｉｏｎ ｏｆ ａｌｌｏｇｅｎｅｉｃ ｉｓｌｅｔｓ ｗｉｔｈ ａｌｌｏｇｅｎｅｉｃ ｔｅｓｔｉｃｕｌａｒ ｃｅｌｌ ａｇｇｒｅｇａｔｅｓ ａｌｌｏｗｓ ｌｏｎｇ−ｔｅｒｍ ｇ", Ｄｉａｂｅｔｅｓ, 1997, Ｖｏｌ．４６， Ｎｏ．２, ｐ．３１７−２２
JPN7010002978, ＷＩＬＬＩＮＧ，Ａ．Ｅ． ｅｔ ａｌ, "Ｓｅｒｔｏｌｉ ｃｅｌｌｓ ｄｅｃｒｅａｓｅ ｍｉｃｒｏｇｌｉａｌ ｒｅｓｐｏｎｓｅ ａｎｄ ｉｎｃｒｅａｓｅ ｅｎｇｒａｆｔｍｅｎｔ ｏｆ ｈｕｍａｎ ｈＮＴ ｎｅｕｒｏｎｓ ｉｎ ｔｈｅ ｈｅｍｉ", Ｂｒａｉｎ Ｒｅｓ Ｂｕｌｌ, 1999, Ｖｏｌ．４８， Ｎｏ．４, ｐ．４４１−４
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Reiko Izumiya