Title:
マトリックスメタロプロテイナーゼの非ペプチドインヒビター
Document Type and Number:
Japanese Patent JP2007530546
Kind Code:
A
Abstract:
Disclosed are selective inhibitors of matrix metalloproteinases represented by the following formula (I). wherein X is (CH2)nO, (CH2)nS, (CH2)nNR1, (CH2)n(CH2), or CH═CH, wherein n=0, 1, or 2; R and R1 are, independently, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl group, cycloalkyl, heterocycloalkyl, cycloalkenyl, or heterocycloalkenyl; and Z is NH or CH2; or a pharmaceutically acceptable salt thereof. Also disclosed are methods of making such compounds and methods of using such compounds to inhibit tumor progression and to treat diseases such as arthritis.
Inventors:
Ananthan, Subra Mania
Application Number:
JP2007505043A
Publication Date:
November 01, 2007
Filing Date:
March 21, 2005
Export Citation:
Assignee:
Southern Research Institute
International Classes:
C07C311/20; A61K31/165; A61K31/41; A61K31/445; A61P17/00; A61P19/02; A61P29/00; A61P35/00; A61P35/04; A61P43/00; C07C311/29; C07C311/43; C07C317/22; C07C317/34; C07D211/14; C07D257/04
Domestic Patent References:
| JP2002535383A | 2002-10-22 |
Foreign References:
| US6326516B1 | 2001-12-04 | |||
| WO2002055491A2 | 2002-07-18 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita