芳香族酸の微生物生産 - Netherlandse Organisatier Folde Toge Pastonatol Wettenchaperik Ondelso Ektienou

Title:

芳香族酸の微生物生産

Document Type and Number:

Japanese Patent JP2007533319

Kind Code:

A

Abstract:

The invention relates to the enzymatic production of aromatic acids using renewable carbon sources, such as sugars. Provided is a method for the microbial production of an aromatic acid from a fermentable carbon substrate using a host cell capable of producing said aromatic acid, for instance cinnamic acid, para-hydroxycinnamic acid (PHCA), and comprising an efflux pump for said aromatic acid. A preferred host cell comprises a member of the proton-dependent resistance/nodulation/cell division (RND) family of efflux pumps, preferably the solvent resistance pump srpABC of P. putida strain S12. Also provided is a method for providing a host cell that overproduces an aromatic acid, comprising subjecting a population of host cells to random insertional mutagenesis, screening said mutated host cells for aromatic acid production and identifying at least one host cell that overproduces said aromatic acid compared to a parent host cell that has not been subjected to random mutagenesis.

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Inventors:

Welly, Yang

Application Number:

JP2007509404A

Publication Date:

November 22, 2007

Filing Date:

December 23, 2004

Export Citation:

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