Title:
ケモカイン受容体活性のテトラヒドロピラニルシクロペンチルテトラヒドロピリドピリジンモジュレーター
Document Type and Number:
Japanese Patent JP2007534756
Kind Code:
A
Abstract:
Compounds of Formula I: (wherein n, R1, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
Inventors:
Yang, Lifou
Mills, Thunder Gee
Jiao, Lichyard
Mills, Thunder Gee
Jiao, Lichyard
Application Number:
JP2007510819A
Publication Date:
November 29, 2007
Filing Date:
April 22, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D309/14; A61K31/351; A61K31/4725; A61K31/4745; A61P1/04; A61P3/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P27/02; A61P29/00; A61P31/00; A61P31/12; A61P31/18; A61P33/00; A61P35/00; A61P37/00; A61P37/02; A61P37/08; A61P39/00; A61P43/00; C07D405/12; C07D471/02
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
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