Title:
ケモカイン受容体活性調節物質であるテトラヒドロピラニルシクロペンチル1-置換及び1,1-二置換テトラヒドロイソキノリン
Document Type and Number:
Japanese Patent JP2007534758
Kind Code:
A
Abstract:
Compounds of Formula I: I (wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
Inventors:
Yang, Lifou
Mills, Thunder Gee
Gregory Jay, Moliero
Gia Dean, Deodiarsin
Shankarang, Kosanda Raman
Mills, Thunder Gee
Gregory Jay, Moliero
Gia Dean, Deodiarsin
Shankarang, Kosanda Raman
Application Number:
JP2007510830A
Publication Date:
November 29, 2007
Filing Date:
April 22, 2005
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D405/12; A61K31/353; A61K31/4375; A61K31/47; A61K31/4725; A61P29/00; A61P37/00; C07D471/04
Attorney, Agent or Firm:
Kenichi Osawa
Yokoyama Isao
Yokoyama Isao