Title:
低減したアレルギー誘発性および保持されたT細胞反応性を有するPhlp5a誘導体
Document Type and Number:
Japanese Patent JP2007536893
Kind Code:
A
Abstract:
Variants (A) of group 5 allergens of the Pooideae that have, relative to the wild-type allergen (B), reduced immunoglobulin E reactivity but essentially unchanged reactivity with T lymphocytes. Independent claims are also included for the following: (1) DNA (I) that encodes (A); (2) recombinant expression vector (EV) that contains (I) and functionally linked expression control sequences; (3) host organisms transformed with (I) or EV; and (4) preparation of (A) by culturing the organisms of (3). ACTIVITY : Antiallergic. No details of tests for antiallergic activity are given. MECHANISM OF ACTION : Immunotherapy (hyposensitization); Vaccine.
Inventors:
Wald, Martin
Cromwell, Oliver
Nadi, Andreas
Carrelt, Helga
Weber, Bernhard
Fevik, Helmut
Cromwell, Oliver
Nadi, Andreas
Carrelt, Helga
Weber, Bernhard
Fevik, Helmut
Application Number:
JP2006508164A
Publication Date:
December 20, 2007
Filing Date:
May 06, 2004
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C12N15/09; A61K31/711; A61K35/76; A61K38/00; A61K39/00; A61K39/35; A61K39/39; A61K48/00; A61P37/04; A61P37/08; C07K14/415; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2002511842A | 2002-04-16 |
Foreign References:
| WO2003025009A1 | 2003-03-27 | |||
| WO2002040676A2 | 2002-05-23 |
Other References:
JPN6010013550, Ｊ． Ｉｍｍｕｎｏｌｏｇｙ， １９９９， Ｖｏｌ．１６２， ｐｐ．２４０６−２４１４
Attorney, Agent or Firm:
Kiyoji Kuzuwa