Title:
化学的安定性が改良された薬用エーロゾル配合物製品
Document Type and Number:
Japanese Patent JP2007537170
Kind Code:
A
Abstract:
The present invention relates to a medicinal aerosol formulation product with improved chemical stability. The product is a pressurized metered dose inhaler including an aerosol canister equipped with a metering valve provided with sealing rings and/or gaskets made of a vulcanisate of an elastomeric composition of a butyl rubber, a cross-linking agent for the butyl rubber, and an accelerator for the cross-linking agent. The accelerator includes a polysulphide compound derived from a substituted dithiocarbonic acid or derivative thereof. The pressurized metered dose inhaler contains in the aerosol canister a medicinal aerosol formulation containing a long acting beta2 agonist, a hydrofluorocarbon propellant, a co-solvent, and a mineral acid as a stabilizer for the active ingredient.
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Inventors:
Brian Meakin
David Lewis
Robert Johnson
Tanya Church
David Lewis
Robert Johnson
Tanya Church
Application Number:
JP2007511888A
Publication Date:
December 20, 2007
Filing Date:
February 25, 2005
Export Citation:
Assignee:
CHIESI FARMACEUTICI S.P.A.
International Classes:
A61K9/12; A61K9/00; A61K9/10; A61K31/4704; A61K47/02; A61K47/06; A61M15/00; A61P11/08; A61P25/02; B65D83/14
Domestic Patent References:
| JP2003534266A | 2003-11-18 |
Foreign References:
| WO2003078538A1 | 2003-09-25 |
Attorney, Agent or Firm:
Yanagawa Yasuo