Title:
新規人工抗原提示細胞およびそれらの用途
Document Type and Number:
Japanese Patent JP2008500052
Kind Code:
A
Abstract:
The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one costimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an "off the shelf" APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit.
Inventors:
Lily the ames el
Ji Yun, Karl H
Bonder Hyde, Robert H
Aqui, Nicole
Suhoski, Megan
Ji Yun, Karl H
Bonder Hyde, Robert H
Aqui, Nicole
Suhoski, Megan
Application Number:
JP2007515334A
Publication Date:
January 10, 2008
Filing Date:
May 25, 2005
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N5/10; A61K35/14; A61K39/00; A61K39/02; A61K39/12; A61K39/21; A61K39/39; A61K48/00; A61P31/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/04; C12N5/078; C12N5/0783; C12N15/09; A61K35/12
Foreign References:
| WO2003057171A2 | 2003-07-17 |
Attorney, Agent or Firm:
Heikichi Odashima